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The Efficacy of Eaulier Rehabilitation Therapies in 44 Patients with Parkinson's Disease
- Categories:Academic Papers
- Author:大连爱丽健康复医院 张峻
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- Time of issue:2018-10-31
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The Efficacy of Eaulier Rehabilitation Therapies in 44 Patients with Parkinson's Disease
(Summary description)Aim: To observe the efficacy of Eaulier
rehabilitation therapies in treating
Parkinson's disease.
- Categories:Academic Papers
- Author:大连爱丽健康复医院 张峻
- Origin:
- Time of issue:2018-10-31
- Views:72
Information
The Efficacy of Eaulier Rehabilitation Therapies in 44 Patients
with Parkinson's Disease
ZHANG Jun
Eaulier (Dalian) Hospital
Abstract
Aim: To observe the efficacy of Eaulier
rehabilitation therapies in treating
Parkinson's disease.
Methods: From September 2013 to
December 2015, 44 patients with primary
Parkinson's disease were treated with
Eaulier rehabilitation therapies. The
changes in the patients’ symptoms and signs,
including resting tremor, stiffness,
bradykinesia, postural and gait
abnormalities, facial expressions, fine hand
movements, insomnia, as well as
constipation, were observed, and efficacy of
the therapies was evaluated based on the
symptoms, signs and Webster ratings. Data
obtained were statistically processed.
Measurement data was analyzed with t-test
and enumeration data with x2-test. If p＜
0.05, there are significant differences.
Results: After treatment, the patients’
symptoms and signs, including resting
tremor, stiffness, bradykinesia, postural and
gait abnormalities, dull facial expressions,
inflexible fine hand movements, insomnia, as
well as constipation, have all shown rather
remarkable improvement. Their ADL levels
have increased significantly, standing at
71.76±8.13 before and 90.97±9.57 after
treatment (p＜0.01). Mini-Mental State
Examination (MMSE) results were
26.84±2.22 before and 27.66±1.23 after
treatment (p＜0.05). Webster’s evaluation
results were 13.85±4.76 before and 7.89
±2.31 after treatment (p＜0.01). Hamilton
Anxiety Rating Scale was 51.99±7.37 before
and 50.75±7.68 after treatment (p＞0.05).
Symptoms and signs such as dull facial
expressions, inflexible fine hand movements,
insomnia and constipation have all shown
rather remarkable improvement.
Conclusion: Eaulier rehabilitation therapies
have good efficacy in treating Parkinson's
disease. They don’t cause any side effects,
are simple to administer, and are worth
promoting.
Keywords:
Eaulier, rehabilitation,
rehabilitation hospital, Parkinson's disease,
micro-current, low- and intermediate
frequency current
Parkinson’s disease (PD) is a common,
chronic, slowly progressing and insidious
degenerative disease of the nervous system.
It usually occurs among the middle-aged and
the elderly, especially those aged above 65.
The prevalence rate of PD in people aged
above 65 is 1.7%. PD is also the fourth most
common neurodegenerative disease among
the elderly, leading to symptoms such as
resting tremor, stiffness, bradykinesia, as
well as postural and gait abnormalities. The
disease progresses gradually, seriously
affecting the quality of life of the patients and
bringing about a heavy burden to their
families and society. Currently, there are no
significantly effective therapies for PD.
Levodopa, Sifrol, Artane and Amantadine are
usually used to treat the disease, but their
effectiveness is uneven. Moreover, they
become less effective after long-term usage
and may cause motor fluctuations, abnormal
actions, illusion, schizophrenia and other
serious side effects. The Eaulier
rehabilitation therapies we have used to treat
44 PD patients have led to rather significant
improvements. The treatment results are
reported below.
1. Data & Methods50
1.1. General Data
All the PD patients selected for this study
suffered from primary PD, and stayed in this
hospital between September 2013 and
December 2015. Of the 44 cases, 28 were
male and 16 were female. Their age ranged
from 53 to 85, with the average age being
67.18 ±9. 39. They had suffered from PD for
periods of 3 months to 13 years, on average
6.5 years ±0.25. They were classified
according to the Hochn _Yahr staging scale
as follows: two patients in Stage 1, four in
Stage 1.5, twelve in Stage 2, five in Stage 2.5,
sixteen in Stage 3, two in Stage 4 and three
in Stage 5. Thirty-five of the cases had been
taking drugs to treat their diseases. Some had
seen drug effectiveness drop while others had
suffered from such serious side effects as
motor fluctuations, abnormal actions,
illusion, schizophrenia, etc. The rules for
inclusion and exclusion of the cases for the
study were as follows: all the 44 cases were
primary PD patients, in accordance with
the ”Standards for the Diagnosis and
Identification of PD and Parkinson’s
syndrome” released at a national seminar on
extrapyramidal system diseases in 1984.
Excluded from the study were patients with
secondary PD, patients with Parkinsonism
plus syndromes, postoperative PD patients,
patients with grave heart, brain, kidney and
mental diseases, pregnant women and those
allergic to electrical stimulus.
1.2. Treatment
Eaulier rehabilitation therapies were
adopted, including 1. Treatment from head to
feet: 20min, 3 times/d; 2. Patch treatment:
patches were fixed at acupuncture points
including Taichong (Liv3), Bailao (GV 14),
Tianzhu (BL10), Shenshu (BL 23), Dazhui
(GV 14) + Mingmen (GV 4), Sanyinjiao (SP
6), Taixi (K 3), Zusanli (ST 36), Qihai (CV6),
Guanyuan (CV 4), etc., 20min, 3 times/d,
working on one group of acupuncture points
at a time; 3. After seven days, brain cell
activation therapy was carried out, 1-3
times/week; 4. Based on the extent of
dysfunction of the patients’ trunk, limb and
speech, PT (exercise therapy), OT
(occupational therapy) or ST (speech
therapy) was carried out, 1 time/day. Thirty
days of the aforementioned treatment was
considered as one course of treatment.
Generally, a patient would be given one to
three such courses on a continuous basis.
1.3. Efficacy Evaluation
Efficacy was evaluated based on changes in
the patients’ symptoms and signs and
according to the Webster rating scale.
Clinical control: Patients’ symptoms and
signs disappeared and the Webster efficacy
index was ＞ 75%:
Very effective：Patients’ symptoms and
signs showed significant improvement and
the Webster efficacy index was between 50%
and 75%;
Effective: Patients’ symptoms and signs
showed improvement and the Webster
efficacy index stood between 30% and 50%;
Ineffective: Patients’ symptoms and signs
showed no change and the Webster efficacy
index was ＜ 30%.
The Webster efficacy index was calculated as
follows: Webster rating before treatment -
Webster rating after treatment / Webster
rating before treatment x 100%.
Standards for the evaluation of other
symptoms and signs were as follows:
Evaluation of:
Tremor: Mild: Tremor amplitude ＜ 2.5cm;
moderate: Tremor amplitude ＜ 10cm;
serious: Tremor amplitude ＞10cm.
Muscle stiffness: Mild: neck and shoulder
rigidity and positive irritation/ positive
excitation?; moderate: moderate neck and
shoulder rigidity when not on medication;
serious: moderate neck and shoulder rigidity
even with medication.
Posture and gait: Mild: Spine becoming rigid
with head flexed forward 12cm; moderate:
Spine becoming rigid with head flexed
forward 15cm; serious: head flexed forward
＞15cm and beginning flexion of knees.51
Insomnia: Mild: 4-6 of sleep; moderate: 2-4
hours of sleep; serious: 1-2 hours of sleep.
Facial expressions: Mild: Slightly immobile
facial expressions; moderate: Moderately
immobile facial expressions and mild
drooling; serious: Severely immobile facial
expressions and severe drooling.
Hand movements: Mild: Slowing of fine
movements and beginning difficulty with
handwriting and button fastening; moderate:
Moderate slowing of hand movements and
obvious impairment of handwriting; serious:
Moderate slowing of hand movements and
unable to write or fasten buttons.
1.4. Statistical Methods
Data obtained were statistically processed.
Measurement data was analyzed with t-test
and enumeration data with x2-test. If p＜
0.05, there were significant differences.
2. Efficacy
2.1. Symptom Alleviation
Changes among two groups of patients in the
following symptoms: resting tremor, muscle
stiffness, posture and gait, bradykinesia,
insomnia, constipation, lower extremity
edema, facial expressions, drooling, fatigue,
handwriting, as well as being able to turn
over.
As shown in Table 1, after treatment with
Eaulier rehabilitation therapies, the patients’
symptoms and signs including resting
tremor, muscle stiffness, postural and gait
abnormalities and bradykinesia have
improved significantly
As shown in Table 2, after treatment with
Eaulier rehabilitation therapies, the patients’
symptoms and signs including insomnia,
constipation, lower extremity edema and dull
facial expressions have improved
significantly.
As shown in Table 3, after treatment with
Eaulier rehabilitation therapies, the patients’
drooling and fatigue have been alleviated,
their handwriting has improved and drug use
has decreased.
2.2. Changes in the objective indexes,
including muscle tension, ADL,
MMSE, Hoffer walking ability
classification and Webster scale,
among the 44 patients
As shown in Table 4, after treatment with
Eaulier rehabilitation therapies, the muscle
tension, ADL, MMSE and Hoffer walking
ability among the 44 patients have all
improved in varying degrees.
As shown in Table 5, after treatment with
Eaulier rehabilitation therapies, the grading
of the patients according to the Hochn _Yahr
staging scale, the Webster scale and the
Hamilton anxiety rating scale has risen or
improved in varying degrees.
As shown in Table 6, after treatment with
Eaulier rehabilitation therapies, 37 cases
have benefited from varying degrees of
improvement in their symptoms and signs,
and their Webster scores have increased. The
clinical treatment has rather beneficial
results, with an overall effectiveness rate
reaching 84.09%.
Table 1: Changes in resting tremor, muscle stiffness, posture and gait, and bradykinesia among the 44
patients
Resting tremor Muscle stiffness Postural and gait abnormalities Bradykinesia
None observed Mild Moderate Serious None observed Mild Moderate Serious None observed Mild
Moderate Serious None observed Mild Moderate Serious
治疗前 8 8 11 17 4 16 17 7 6 6 23 9 1 8 24 11
Before treatment
治疗后 19 14 9 2 20 21 3 22 17 5 22 19 3
After treatment
Table 2: Changes in insomnia, constipation, lower extremity edema and facial expressions among the 44
patients52
失眠 便秘 下肢浮肿 面容（面具脸）
Insomnia Constipation Lower extremity edema Face (mask-like face)
未见 轻度 中度 重度 未见 轻度 中度 重度 未见 轻度 中度 重度 未见 轻度 中度 重度
None observed Mild Moderate Serious None observed Mild Moderate Serious None observed Mild Moderate
Serious None observed Mild Moderate Serious
治疗前 20 7 10 7 26 3 8 7 21 7 11 5 18 11 12 3
Before treatment
治疗后 29 14 1 31 10 2 1 43 1 23 19 2
After treatment
Table 3 Changes in drooling, fatigue, handwriting and drug use among the 44 patients
流涎 疲劳 手动作（不灵活） 用药
Drooling Fatigue Hand movements (inflexible) Drug use
未见 轻度 中度 重度 未见 轻度 中度 重度 未见 轻度 中度 重度 未用 少量 中度 大量
None observed Mild Moderate Serious None observed Mild Moderate Serious None observed Mild
Moderate Serious None observed Mild Moderate Serious
治疗前 19 18 5 2 9 9 19 7 3 9 22 10 3 18 20 3
Before treatment
治疗后 40 4 22 18 4 21 14 9 9 28 7
After treatment
Table 4: Changes in muscle tension, ADL, MMSE and Hoffer walking ability among the 44 patients
肌张力 日常生活活动（ADL） 精神状态简易量表（ＭＭＳＥ） Hoffer步行能力分级
Muscle tension ADL MMSE Hoffer walking ability classification
0级 1级 2级3级4级5级 Ⅰ级 Ⅱ级 Ⅲ级 Ⅳ
Level 0 Level 1 Level 2 Level 3 Level 4 Level 5 Level I Level II Level III Level IV
治疗前 4 19 17 4 71.16±8.13 26.84±2.22 6 12 12 14
Before treatment
治疗后 22 17 5 90.97±9.57 27.66±1.23 1 4 13 26
After treatment
T 值 5.26 3.48
T value
P 值 p＜0.01 p＜0.05
P value
Table 5 Changes in Hochn _Yahr staging, Webster scale and Hamilton anxiety rating scale among the 44
patients
Hochn _Yahr staging Webster scale Hamilton anxiety rating scale
0级 1级 1.5级2级 2.5级 3级 4级5级
Stage 0 Stage 1 Stage 1.5 Stage 2 Stage 2.5 Stage 3 Stage 4 Stage 5
治疗前 2 8 10 5 14 2 3 13.85±4.76 51.99±7.37
Before treatment
治疗后 6 29 6 3 7.89 ±2.31 50.76±7.68
After treatment
T 值 8.94 1.79
T value
P 值 p＜0.01 p＞0.05
P value53
Table 6: Evaluation of the Overall Clinical Efficacy of the Eaulier rehabilitation therapies among the44
patients
Patient number Basically cured Very effective Effective Ineffective Very effective rate (%) Overall effective
rate (%)
2.3. Safety Observation
Three patients suffered from adverse
reactions during the course of treatment, with
one case of dizziness, one case of palpitation
and one case of insomnia. These cases were
not separately dealt with. However, their
adverse reactions disappeared after the
continuation of treatment.
3. Discussions
PD is a common chronic nervous system
disease that usually occurs among the
middle-aged and the elderly，especially
among the age group above 65, where the
prevalence rate of PD is as high as 1.7%. PD
is also the fourth most common
neurodegenerative disease among the
elderly. The major symptoms are resting
tremor, stiffness, bradykinesia, as well as
postural and gait abnormalities. The disease
comes on insidiously and progresses
gradually, usually becoming more and more
severe and seriously affecting the quality of
life of the patients, bringing about a heavy
burden to their families and society. The
treatment of PD has always been widely
recognized in the world’s medical circle as a
difficult problem, and currently, there is no
significantly effective cure for the disease. L
dopa and dopamine receptor agonist are
usually used in clinical treatment of PD, but
their effectiveness is uneven. Moreover,
these drugs become less effective after long
term use and may bring about grave side
effects such as motor fluctuations, abnormal
actions, illusion and schizophrenia.
Using Eaulier rehabilitation therapies, we
have achieved relatively significant efficacy
in the treatment of PD. After one to three
courses of treatment, the clinical symptoms
and signs of 44 PD patients -- including
resting tremor, muscle stiffness, postural and
gait abnormalities, bradykinesia, insomnia,
constipation, lower extremity edema, dull
facial expressions, drooling, fatigue and
micrographia – were all significantly
alleviated. In addition, the patients’ muscle
tension, ADL, MMSE, Hoffer walking
ability classification and Webster score have
also improved. The results of this study
showed that Eaulier rehabilitation therapies
are relatively efficacious in treating PD
patients, and are worth promoting.
The Eaulier systemic current therapy is a new
kind of electrotherapy that applies weak low
and intermediate-frequency current to the
human body to help prevent and cure
diseases. It integrates the functions of health
preservation, disease prevention and
treatment. This new micro current therapy
has been jointly developed by Japanese and
Chinese scientific teams after many years of
research, using brand new science and
technologies and unique medical design. It
is a perfect integration of modern Western
electrotherapy and traditional Chinese
acupuncture therapy. By transmitting a
special form of electric current through
various reflex zones in the central nervous
system including the sole, the palm and the
head, through the projection zones of the
central nervous system in the head, and
through special acupuncture points, the
therapy provides supplementary bioelectric
energy to human tissues. This process helps
to revitalize the human body, decelerate
aging, relieve various pains, and significantly
improve the functions of major organs such
as the heart and the brain. It gives full play to
self-healing abilities, promotes recovery
from various kinds of diseases, and cures
some diseases believed to be incurable by the
medical industry, such as PD, stroke
sequelae, dementia, depression and other
chronic diseases. It is widely used in the
treatment of cardiovascular diseases, nervous
system diseases, bone and joint diseases, as
well as digestive, respiratory, endocrine and
other systemic diseases. 54
It is widely known that the some function
control areas of the central nervous systems
of the brain and the spinal cord, such as those
for the nerve, digestive, circulatory and
endocrine systems, have corresponding
reflex and projection areas at the sole, the
hand and the head. In the course of Eaulier
systemic current therapy, Eaulier electrical
currents stimulate these reflex and projection
areas and through conditioned reflex adjust
the functions of the central and autonomic
nervous systems to boost the electrical
activities of the brain cells. The resonance
induces the emergence and increase of
rhythmic brain waves, decreases abnormal
brain waves and activates inhibited brain
cells to promote the orderly electrical
activities of the brain. This helps the
confused central nervous system to adjust
and revive, thereby working on the various
nerve centers of the brain and affecting the
functions of various systems including the
body’s nerves, metabolism, circulation,
respiration, digestion, and endocrine
systems.
In the course of the Eaulier systemic current
therapy, brain tissues also release kinin,
bradykinin, acetylcholine, serotonin and
other neurotransmitter mediators and
vasoactive substances, causing a series of
reactions. For example, the Eaulier electrical
currents stimulate brain substantia nigra,
striatum and globus pallidus, releasing an
increased level of dopamine, serotonin and
neurotransmitter. This helps to alleviate the
symptoms that affect most PD patients, such
as hand and foot tremor, stiffness and lack of
movement, thereby facilitating their
activities and improving the mental state of
the patients. The Eaulier electric current can
expand blood vessels in the brain, promote
collateral circulation, relieve the hypoxia
state of the brain tissues, improve blood
supply and accelerate the repair of damaged
brain cells.
The human hand is where the meridians of
the hand, three yin and three yang, intersect,
while the foot is where the meridians of the
foot, three yin and three yang, intersect. In
addition, the eight channels of Ren, Du,
Chong, Dai, Yangqiao, Yinqiao, Yangwei and
Yinwei, the branches of the twelve meridians,
the muscle along the twelve regular
meridians, and the twelve cortexes also
connect with the aforementioned twelve
channels. They are distributed throughout the
body and form a huge network of meridians
(jingluo). Meridians are the channels for the
distribution of vitality (qi) and blood in
human bodies. They are part of the internal
organs, run all over the body, and adjust the
functions of all the organs. The Eaulier
treatment of the entire body runs the Eaulier
current through the hand and the foot,
stimulating particular acupuncture points in
the hand and foot, opening up the channels to
facilitate the distribution of vitality and blood
circulation, and enhancing the functions of
the organs. Treatment with the Eaulier patch
and the activation of brain cells also work
through the operation of the Eaulier electric
current on various meridians and
acupuncture points, opening up the channels
and facilitating the distribution of vitality and
blood circulation, enhancing the functions of
the organs to help prevent disease and
strengthen the body.
In summary, the Eaulier electrical current can
expand blood vessels in the brain, promote
collateral circulation, increase the supply of
oxygen and blood to the brain tissues,
activate enzymes, facilitate neurotransmitter
release, accelerate the metabolism of the
brain tissues and the repair of damaged cells,
and improve the functions of the central and
autonomic nervous systems. It also boosts
the bioelectric activity of the brain cells, and
through resonance, induces rhythmic brain
waves and decreases abnormal brain waves,
activating inhibited brain cells to promote the
orderly activities of the brain cells so that the
disorderly functions of the brain and the
nervous system can be adjusted and revived.
参考文献
References 55
1、陈景藻·现代物理治疗学·北京：人
民军医出版社·2001年。
1. CHEN Jingzao. Modern Physical
Therapy. Beijing: People’s Military
Medical Press, 2001 (in Chinese)
2、乔志恒·新编物理治疗学·北京：华
夏出版社·1993年。
2. QIAO Zhiheng. New Physical
Therapy. Beijing: Huaxia Publishing
House, 1993 (in Chinese)
3、卓大宏·中国康复医学·北京：华夏
出版社·1990年。
3. ZHUO Dahong. Rehabilitation
Medicine in China. Beijing: Huaxia
Publishing House, 1990 (in Chinese)
4、张福金·帕金森病患者的物理治
疗·国外医学—物理医学与康复分
册，1990,4,174.
4. ZHANG Fujin. Physical Therapy for
Patients with Parkinson’s Disease.
Foreign Medical Sciences (Physical
Medical and Rehabilitation), 1990,
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